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isomer 3tc  (CEM Corporation)

 
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    Structured Review

    CEM Corporation isomer 3tc
    Mechanism of antiviral action of 1,3-oxathiolane nucleosides, <t>3TC</t> ( 1 ) and FTC ( 2 ), as chain terminators.
    Isomer 3tc, supplied by CEM Corporation, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/isomer+3tc/ic+50+values/pmc08576827-267-11-21
    Average 90 stars, based on 1 article reviews
    isomer 3tc - by Bioz Stars, 2026-10
    90/100 stars

    Images

    1) Product Images from "Synthetic strategies toward 1,3-oxathiolane nucleoside analogues"

    Article Title: Synthetic strategies toward 1,3-oxathiolane nucleoside analogues

    Journal: Beilstein Journal of Organic Chemistry

    doi: 10.3762/bjoc.17.182

    Mechanism of antiviral action of 1,3-oxathiolane nucleosides, 3TC ( 1 ) and FTC ( 2 ), as chain terminators.
    Figure Legend Snippet: Mechanism of antiviral action of 1,3-oxathiolane nucleosides, 3TC ( 1 ) and FTC ( 2 ), as chain terminators.

    Techniques Used:

    First synthesis of (±)-BCH-189 ( 1c ) by Belleau et al.
    Figure Legend Snippet: First synthesis of (±)-BCH-189 ( 1c ) by Belleau et al.

    Techniques Used:

    Enantioselective synthesis of 3TC ( 1 ).
    Figure Legend Snippet: Enantioselective synthesis of 3TC ( 1 ).

    Techniques Used:

    Synthesis of cis- diastereomer 3TC ( 1 ) from oxathiolane propionate 44 .
    Figure Legend Snippet: Synthesis of cis- diastereomer 3TC ( 1 ) from oxathiolane propionate 44 .

    Techniques Used:

    Synthesis of (±)-BCH-189 ( 1c ) via SnCl 4 -mediated N-glycosylation of 8 .
    Figure Legend Snippet: Synthesis of (±)-BCH-189 ( 1c ) via SnCl 4 -mediated N-glycosylation of 8 .

    Techniques Used:

    Synthesis of (+)-BCH-189 ( 1a ) via TMSOTf-mediated N-glycosylation of 20 .
    Figure Legend Snippet: Synthesis of (+)-BCH-189 ( 1a ) via TMSOTf-mediated N-glycosylation of 20 .

    Techniques Used:

    Synthesis of 3TC ( 1 ) from oxathiolane precursor 20a .
    Figure Legend Snippet: Synthesis of 3TC ( 1 ) from oxathiolane precursor 20a .

    Techniques Used:

    Synthesis of 3TC ( 1 ) via TMSI-mediated N-glycosylation.
    Figure Legend Snippet: Synthesis of 3TC ( 1 ) via TMSI-mediated N-glycosylation.

    Techniques Used:

    Enzymatic resolution of the monophosphate derivative 116 for the synthesis of (−)-BCH-189 ( 1 ) and (+)-BCH-189 ( 1a ).
    Figure Legend Snippet: Enzymatic resolution of the monophosphate derivative 116 for the synthesis of (−)-BCH-189 ( 1 ) and (+)-BCH-189 ( 1a ).

    Techniques Used:

    Related Articles

    other:

    Article Title: Synthetic strategies toward 1,3-oxathiolane nucleoside analogues
    Article Snippet: Separation by chromatography and deprotection with TBAF in THF afforded the (−)-isomer 3TC ( 1 , EC50 = 0.07 μM in CEM cells) and the trans -isomer 1b .



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    Image Search Results


    Mechanism of antiviral action of 1,3-oxathiolane nucleosides, 3TC ( 1 ) and FTC ( 2 ), as chain terminators.

    Journal: Beilstein Journal of Organic Chemistry

    Article Title: Synthetic strategies toward 1,3-oxathiolane nucleoside analogues

    doi: 10.3762/bjoc.17.182

    Figure Lengend Snippet: Mechanism of antiviral action of 1,3-oxathiolane nucleosides, 3TC ( 1 ) and FTC ( 2 ), as chain terminators.

    Article Snippet: Separation by chromatography and deprotection with TBAF in THF afforded the (−)-isomer 3TC ( 1 , EC50 = 0.07 µM in CEM cells) and the trans -isomer 1b .

    Techniques:

    First synthesis of (±)-BCH-189 ( 1c ) by Belleau et al.

    Journal: Beilstein Journal of Organic Chemistry

    Article Title: Synthetic strategies toward 1,3-oxathiolane nucleoside analogues

    doi: 10.3762/bjoc.17.182

    Figure Lengend Snippet: First synthesis of (±)-BCH-189 ( 1c ) by Belleau et al.

    Article Snippet: Separation by chromatography and deprotection with TBAF in THF afforded the (−)-isomer 3TC ( 1 , EC50 = 0.07 µM in CEM cells) and the trans -isomer 1b .

    Techniques:

    Enantioselective synthesis of 3TC ( 1 ).

    Journal: Beilstein Journal of Organic Chemistry

    Article Title: Synthetic strategies toward 1,3-oxathiolane nucleoside analogues

    doi: 10.3762/bjoc.17.182

    Figure Lengend Snippet: Enantioselective synthesis of 3TC ( 1 ).

    Article Snippet: Separation by chromatography and deprotection with TBAF in THF afforded the (−)-isomer 3TC ( 1 , EC50 = 0.07 µM in CEM cells) and the trans -isomer 1b .

    Techniques:

    Synthesis of cis- diastereomer 3TC ( 1 ) from oxathiolane propionate 44 .

    Journal: Beilstein Journal of Organic Chemistry

    Article Title: Synthetic strategies toward 1,3-oxathiolane nucleoside analogues

    doi: 10.3762/bjoc.17.182

    Figure Lengend Snippet: Synthesis of cis- diastereomer 3TC ( 1 ) from oxathiolane propionate 44 .

    Article Snippet: Separation by chromatography and deprotection with TBAF in THF afforded the (−)-isomer 3TC ( 1 , EC50 = 0.07 µM in CEM cells) and the trans -isomer 1b .

    Techniques:

    Synthesis of (±)-BCH-189 ( 1c ) via SnCl 4 -mediated N-glycosylation of 8 .

    Journal: Beilstein Journal of Organic Chemistry

    Article Title: Synthetic strategies toward 1,3-oxathiolane nucleoside analogues

    doi: 10.3762/bjoc.17.182

    Figure Lengend Snippet: Synthesis of (±)-BCH-189 ( 1c ) via SnCl 4 -mediated N-glycosylation of 8 .

    Article Snippet: Separation by chromatography and deprotection with TBAF in THF afforded the (−)-isomer 3TC ( 1 , EC50 = 0.07 µM in CEM cells) and the trans -isomer 1b .

    Techniques:

    Synthesis of (+)-BCH-189 ( 1a ) via TMSOTf-mediated N-glycosylation of 20 .

    Journal: Beilstein Journal of Organic Chemistry

    Article Title: Synthetic strategies toward 1,3-oxathiolane nucleoside analogues

    doi: 10.3762/bjoc.17.182

    Figure Lengend Snippet: Synthesis of (+)-BCH-189 ( 1a ) via TMSOTf-mediated N-glycosylation of 20 .

    Article Snippet: Separation by chromatography and deprotection with TBAF in THF afforded the (−)-isomer 3TC ( 1 , EC50 = 0.07 µM in CEM cells) and the trans -isomer 1b .

    Techniques:

    Synthesis of 3TC ( 1 ) from oxathiolane precursor 20a .

    Journal: Beilstein Journal of Organic Chemistry

    Article Title: Synthetic strategies toward 1,3-oxathiolane nucleoside analogues

    doi: 10.3762/bjoc.17.182

    Figure Lengend Snippet: Synthesis of 3TC ( 1 ) from oxathiolane precursor 20a .

    Article Snippet: Separation by chromatography and deprotection with TBAF in THF afforded the (−)-isomer 3TC ( 1 , EC50 = 0.07 µM in CEM cells) and the trans -isomer 1b .

    Techniques:

    Synthesis of 3TC ( 1 ) via TMSI-mediated N-glycosylation.

    Journal: Beilstein Journal of Organic Chemistry

    Article Title: Synthetic strategies toward 1,3-oxathiolane nucleoside analogues

    doi: 10.3762/bjoc.17.182

    Figure Lengend Snippet: Synthesis of 3TC ( 1 ) via TMSI-mediated N-glycosylation.

    Article Snippet: Separation by chromatography and deprotection with TBAF in THF afforded the (−)-isomer 3TC ( 1 , EC50 = 0.07 µM in CEM cells) and the trans -isomer 1b .

    Techniques:

    Enzymatic resolution of the monophosphate derivative 116 for the synthesis of (−)-BCH-189 ( 1 ) and (+)-BCH-189 ( 1a ).

    Journal: Beilstein Journal of Organic Chemistry

    Article Title: Synthetic strategies toward 1,3-oxathiolane nucleoside analogues

    doi: 10.3762/bjoc.17.182

    Figure Lengend Snippet: Enzymatic resolution of the monophosphate derivative 116 for the synthesis of (−)-BCH-189 ( 1 ) and (+)-BCH-189 ( 1a ).

    Article Snippet: Separation by chromatography and deprotection with TBAF in THF afforded the (−)-isomer 3TC ( 1 , EC50 = 0.07 µM in CEM cells) and the trans -isomer 1b .

    Techniques: